DNA methylation profiles in monozygotic and dizygotic twins

@article{Kaminsky2009DNAMP,
  title={DNA methylation profiles in monozygotic and dizygotic twins},
  author={Zachary A. Kaminsky and Thomas Tang and Sun-Chong Wang and Carolyn Ptak and Gabriel Oh and Albert Hung Choy Wong and Laura A. Feldcamp and Carl Virtanen and Jonas Halfvarson and Curt Tysk and Allan F. McRae and Peter M. Visscher and Grant W. Montgomery and Irving I Gottesman and Nicholas G. Martin and Artūras Petronis},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={240-245}
}
Twin studies have provided the basis for genetic and epidemiological studies in human complex traits. As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays. Here we provide the first annotation of epigenetic metastability of ∼6,000 unique genomic… 

DNA methylation variations between mono - and dizygotic twins

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This study was the first to utilize epigenomewide profiling to document DNA methylation differences in MZ twins, and found that DZ twins exhibited more epigenetic differences compared to MZ siblings.

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TLDR
It is suggested that CpG methylation profile could be a useful biomarker in individual identification of MZs, which exhibited remarkable differences of genome-wide 5-methylcytosine.

Epigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylation in Buccal Cells

TLDR
The findings indicate that it is worthwhile to examine heritable and shared environmental influences on buccal DNA methylation in larger studies that also include dizygotic twins, and suggests that individual-specific environmental and stochastic influences account for more variation in DNAmethylation in CpG-poor regions.

Intra-Monozygotic Twin Pair Discordance and Longitudinal Variation of Whole-Genome Scale DNA Methylation in Adults

TLDR
It is demonstrated that, on whole-genome level, there has been no significant epigenetic drift within the same individuals for up to 9 months, including one monozygotic twin pair, and a subset of CpG sites that vary in DNA methylation over the 9-month period are identified.

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TLDR
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TLDR
Differences in the sperm epigenome may contribute to incongruous diverging performances of daughters sired by bulls that are MZ twins.

DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome.

TLDR
The intrauterine period is confirmed as a sensitive time for the establishment of epigenetic variability in humans and an epigenetic mechanism for the previously described phenomenon of 'fetal programming' of disease risk is supported.

Epigenetics of discordant monozygotic twins: implications for disease

TLDR
Advances in epigenetic studies of discordant MZ twins, focusing on disease, help to identify epigenetic markers of environmental risk and molecular mechanisms involved in disease and disease progression, which have implications both for understanding disease and for future medical research.
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