• Biology, Medicine
  • Published in
    Clinical cancer research : an…
    2002

DNA methylation patterns at relapse in adult acute lymphocytic leukemia.

@article{GarciaManero2002DNAMP,
  title={DNA methylation patterns at relapse in adult acute lymphocytic leukemia.},
  author={Guillermo Garcia-Manero and Carlos Bueso-Ramos and Jerry Daniel and Jason Williamson and Hagop M Kantarjian and J P Issa},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 6},
  pages={
          1897-903
        }
}
PURPOSE Aberrant DNA methylation of promoter-associated CpG islands is an epigenetic DNA modification observed in acute leukemias that in certain cases has been associated with a poor prognosis and increased relapse rates. To study the role of DNA methylation in relapse mechanisms in acute lymphocytic leukemia (ALL), we have compared the methylation status of five genes at the time of initial presentation and at first relapse in 25 adult patients with ALL. EXPERIMENTAL DESIGN Genes studied… CONTINUE READING

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