DNA methylation patterns at relapse in adult acute lymphocytic leukemia.

@article{GarciaManero2002DNAMP,
  title={DNA methylation patterns at relapse in adult acute lymphocytic leukemia.},
  author={Guillermo Garcia-Manero and Carlos E Bueso-Ramos and Jerry Daniel and Jason B Williamson and Hagop M Kantarjian and Jean-Pierre Issa},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 6},
  pages={1897-903}
}
PURPOSE Aberrant DNA methylation of promoter-associated CpG islands is an epigenetic DNA modification observed in acute leukemias that in certain cases has been associated with a poor prognosis and increased relapse rates. To study the role of DNA methylation in relapse mechanisms in acute lymphocytic leukemia (ALL), we have compared the methylation status of five genes at the time of initial presentation and at first relapse in 25 adult patients with ALL. EXPERIMENTAL DESIGN Genes studied… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

COBRA: a sensitive and quantitative DNA methylation assay.

Nucleic acids research • 1997
View 9 Excerpts
Highly Influenced

CpG island methylation profile in acute lymphocytic leukemia

G. Garcia-Manero, J. Daniel, +4 authors J-P
(ALL). Blood, • 2000
View 5 Excerpts
Highly Influenced

Estrogen receptor methylation is associated with improved survival in adult acute myeloid leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research • 1999
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…