DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

  title={DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer},
  author={Andrew E. Teschendorff and Yang Gao and Allison Jones and Matthias Ruebner and Matthias W. Beckmann and David Wachter and Peter A. Fasching and Martin Widschwendter},
  booktitle={Nature communications},
Identifying molecular alterations in normal tissue adjacent to cancer is important for understanding cancer aetiology and designing preventive measures. Here we analyse the DNA methylome of 569 breast tissue samples, including 50 from cancer-free women and 84 from matched normal cancer pairs. We use statistical algorithms for dissecting intra- and inter-sample cellular heterogeneity and demonstrate that normal tissue adjacent to breast cancer is characterized by tens to thousands of epigenetic… CONTINUE READING
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