DNA methylation on N6-adenine in mammalian embryonic stem cells

  title={DNA methylation on N6-adenine in mammalian embryonic stem cells},
  author={Tao Wu and Tao T. Wang and Matthew G. Seetin and Yongquan Lai and Shijia Zhu and Kaixuan Lin and Yifei Liu and Stephanie D. Byrum and Samuel G. Mackintosh and Mei Zhong and Alan J. Tackett and Guilin Wang and Lawrence S. Hon and Gang Fang and James A. Swenberg and Andrew Z. Xiao},
It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes. Here we identify N6-methyladenine as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a demethylase for N6-methyladenine. An increase of N6-methyladenine levels in Alkbh1-deficient cells leads to transcriptional silencing. N6-methyladenine deposition is inversely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched… CONTINUE READING


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