DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells.

@article{Chimonidou2011DNAMO,
  title={DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells.},
  author={Maria Chimonidou and Areti Strati and Alexandra Tzitzira and Georgia Sotiropoulou and Nikos A. Malamos and Vassilis Georgoulias and Evi Lianidou},
  journal={Clinical chemistry},
  year={2011},
  volume={57 8},
  pages={
          1169-77
        }
}
BACKGROUND Circulating tumor cells (CTCs) are associated with prognosis in a variety of human cancers and have been proposed as a liquid biopsy for follow-up examinations. We show that tumor suppressor and metastasis suppressor genes are epigenetically silenced in CTCs isolated from peripheral blood of breast cancer patients. METHODS We obtained peripheral blood from 56 patients with operable breast cancer, 27 patients with verified metastasis, and 23 healthy individuals. We tested DNA… CONTINUE READING

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