DNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q

@article{Bello2004DNAMO,
  title={DNA methylation of multiple promoter-associated CpG islands in meningiomas: relationship with the allelic status at 1p and 22q},
  author={Maria Josefa Bello and Cinthia Ami{\~n}oso and Isabel Lopez-Mar{\'i}n and Dolores Arjona and Pilar Gonz{\'a}lez-G{\'o}mez and Margarita Alonso and J. Derek Lomas and Jos{\'e} Marcello Salabert de Campos and Michael Kusak and Jes{\'u}s Vaquero and Alberto Isla and Manuel S{\'a}nchez Guti{\'e}rrez and Jos{\'e} Luis Sarasa and Juan Antonio Rey},
  journal={Acta Neuropathologica},
  year={2004},
  volume={108},
  pages={413-421}
}
The purpose of this research was to examine the DNA methylation profile of meningiomas. Accordingly, we examined the DNA methylation status of ten tumor-related genes (RB1, p16 INK4a , p73, MGMT, ER, DAPK, TIMP-3, p14 ARF , THBS1, and Caspase-8) in 98 meningiomas (68 grade I; 27 grade II; and 3 grade III samples) using methylation-specific PCR and sequencing. The most frequently methylated genes were THBS1 (30%), TIMP-3 (24%), p16 INK4a (17%), MGMT (16%), p73 (15%), ER (15%), and p14 ARF (13… CONTINUE READING
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