DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection.

@article{Kaur2010DNAMO,
  title={DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection.},
  author={Pushpinder Kaur and Anupam Paliwal and David Durantel and Pierre Hainaut and J. -Y. Scoazec and Fabien Zoulim and Isabelle Chemin and Zdenko Herceg},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={202 5},
  pages={700-4}
}
Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and have suggested that it may be an important mechanism regulating transcription and replication of the HBV virus. However, it remains unclear whether this phenomenon is associated with occult hepatitis. Here, we performed a detailed analysis of DNA methylation in the HBV genome in liver samples of patients at different stages of hepatocarcinoma development and in in vitro infected hepatocytes and… CONTINUE READING