DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer

@inproceedings{Zhou2017DNAMO,
  title={DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer},
  author={Shasha Zhou and Yihang Shen and Min Zheng and Linlin Wang and Raymond Che and Wanning Hu and Peipei Li},
  booktitle={Oncotarget},
  year={2017}
}
DNA methylation is the best-studied epigenetic mechanism for regulating gene transcription and maintaining genome stability. Current research progress of transcriptional regulation by DNA methylation mostly focuses on promoter region where hypomethylated CpG islands are present transcriptional activity, as hypermethylated CpG islands generally result in gene repression. Recently, the DNA methylation patterns across the gene body (intragenic methylation) have increasingly attracted attention… CONTINUE READING