DNA methylation mediated up-regulation of TERRA non-coding RNA is coincident with elongated telomeres in the human placenta.

@article{Novakovic2016DNAMM,
  title={DNA methylation mediated up-regulation of TERRA non-coding RNA is coincident with elongated telomeres in the human placenta.},
  author={Boris Novakovic and Christine E Napier and Regan Vryer and Evdokia Dimitriadis and Ursula Manuelpillai and Andrew M Sharkey and Jeffrey M Craig and Roger R Reddel and Richard Saffery},
  journal={Molecular human reproduction},
  year={2016},
  volume={22 11},
  pages={791-799}
}
STUDY QUESTION What factors regulate elongated telomere length in the human placenta? SUMMARY ANSWER Hypomethylation of TERRA promoters in the human placenta is associated with high TERRA expression, however, no clear mechanistic link between these phenomena and elongated telomere length in the human placenta was found. WHAT IS KNOWN ALREADY Human… CONTINUE READING