DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter.

@article{Smet1999DNAMI,
  title={DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter.},
  author={Charles de Smet and Christophe Lurquin and Bernard Leth{\'e} and Val{\'e}rie Martelange and T. Boon},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 11},
  pages={7327-35}
}
A subset of male germ line-specific genes, the MAGE-type genes, are activated in many human tumors, where they produce tumor-specific antigens recognized by cytolytic T lymphocytes. Previous studies on gene MAGE-A1 indicated that transcription factors regulating its expression are present in all tumor cell lines whether or not they express the gene. The analysis of two CpG sites located in the promoter showed a strong correlation between expression and demethylation. It was also shown that MAGE… CONTINUE READING