DNA methylation is related to the occurrence of breast cancer and is not affected by culture conditions.
@article{Wang2018DNAMI, title={DNA methylation is related to the occurrence of breast cancer and is not affected by culture conditions.}, author={Shibao Wang and Yinghui Huang and Xupeng Mu and Tianyang Qi and Sha Qiao and Zhenxia Lu and Hong-jun Li}, journal={Molecular medicine reports}, year={2018}, volume={17 5}, pages={ 7365-7371 } }
The present study aimed to explore the relationship between DNA methylation and breast cancer under different cell culture conditions. MCF‑7 breast cancer cells were cultured in two‑dimensional (2D), three‑dimensional (3D) and orthotopic transplantation (Ti) adhesion substrates. Principal component analysis (PCA) was used for global visualization of these three samples. The methylation status of CpG sites was examined by unsupervised clustering analysis. Scatter plots and histograms were…
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References
SHOWING 1-10 OF 38 REFERENCES
DNA hypermethylation in breast cancer and its association with clinicopathological features.
- Medicine, BiologyCancer letters
- 2006
DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma
- Biology, MedicineInternational journal of cancer
- 2003
The methylation profiles of lobular vs. ductal carcinomas with respect to RASSF1A, Cyclin D2, RARβ, and Hin‐1 genes were similar, suggesting that gene silencing by promoter hypermethylation is likely to be important in both groups of diseases.
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer.
- BiologyCancer research
- 2006
Biological and mechanistic insights are provided into RUNX3 as the key member of the family that plays a role in breast cancer and Frequent protein mislocalization and methylation could render RunX3 a valuable marker for early detection and risk assessment.
Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer
- Biology, MedicineEpigenetics
- 2013
New candidate biomarker genes for cervical cancer represent several types of mechanisms in the cellular machinery that are epigenetically deregulated by hypermethylation, such as membrane receptors, intracellular signaling and gene transcription.
Transcriptional Gene Silencing Promotes DNA Hypermethylation through a Sequential Change in Chromatin Modifications in Cancer Cells
- BiologyCancer Research
- 2004
It is demonstrated that the seeds of DNA methylation also play an important role in initiating chromatin modification, and these findings have important implications for understanding the biochemical events underlying the mechanisms responsible for abnormal hypermethylation of CpG island-associated genes in cancer cells.
CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia
- BiologyJournal of Hematology & Oncology
- 2014
A novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement that is associated with genes previously described as upregulated in inv( 16) AML is reported.
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
- BiologyCancer research
- 2008
PI3K pathway aberrations likely play a distinct role in the pathogenesis of different breast cancer subtypes and the specific aberration present may have implications for the selection of PI3K-targeted therapies in hormone receptor-positive breast cancer.
Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk.
- MedicineClinical cancer research : an official journal of the American Association for Cancer Research
- 2005
Since cyclin D2 promoter methylation occurs almost exclusively in tumors, it may be possible to exploit it for the early detection of breast cancer.
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
- BiologyNature Genetics
- 2009
Substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine island shores in nine human iPS cell lines as compared to their parental fibroblasts are found, suggesting two mechanisms for epigenetic reprogramming in iPS cells and cancer.
DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish
- BiologyJournal of Hematology & Oncology
- 2015
Dnmt1 is required for HSPC maintenance via cebpa regulation during definitive hematopoiesis in zebrafish through its role in maintaining parental DNA methylation patterns on daughter DNA strands during mitosis.