DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

@article{Boyes1991DNAMI,
  title={DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein},
  author={JohnF. Boyes and Adrian Bird},
  journal={Cell},
  year={1991},
  volume={64},
  pages={1123-1134}
}
We have studied the mechanism by which DNA methylation inhibits transcription both in cell-free nuclear extracts and in the living cell. Repression of transcription in vitro for four different promoters was shown to be an indirect effect. The mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified. Use of differentially methylated promoters and methylated competitors in transient transfection assays… CONTINUE READING
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