DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2.

@article{ChertkowDeutsher2010DNAMI,
  title={DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2.},
  author={Yael Chertkow-Deutsher and Hagit Cohen and Ehud Klein and Dorit Ben-Shachar},
  journal={The international journal of neuropsychopharmacology},
  year={2010},
  volume={13 3},
  pages={347-59}
}
Post-traumatic stress disorder (PTSD) is unique among psychiatric disorders since there is an explicit requirement for the presence of a well-defined precipitating environmental event. This suggests the participation of adaptable molecular processes such as epigenetic modifications, including acetylation and methylation of histones and DNA methylation. In the present study we investigated whether changes in DNA methylation are associated with the effects of traumatic stressor, using a validated… CONTINUE READING