DNA methylation in the CTCF-binding site I and the expression pattern of the H19 gene: does positive expression predict poor prognosis in early stage head and neck carcinomas?

@article{Esteves2005DNAMI,
  title={DNA methylation in the CTCF-binding site I and the expression pattern of the H19 gene: does positive expression predict poor prognosis in early stage head and neck carcinomas?},
  author={Leda Isabel C V Esteves and Afonso C Javaroni and In{\^e}s Nobuko Nishimoto and Jos{\'e} Magrin and Jeremy A Squire and Luiz Paulo Kowalski and Cl{\'a}udia Aparecida Rainho and S{\'i}lvia Regina Rogatto},
  journal={Molecular carcinogenesis},
  year={2005},
  volume={44 2},
  pages={102-10}
}
Loss of allele-specific expression by the imprinted genes IGF2 and H19 has been correlated with a differentially methylated region (DMR) upstream to the H19 gene. The H19-DMR contains seven potential CCCTC-binding factor (CTCF) binding sites. CTCF is a chromatin insulator and a multifunctional transcription factor whose binding to the H19-DMR is suppressed by DNA methylation. Our study included a group of 41 head and neck squamous cell carcinoma (HNSCC) samples. The imprinting status of the H19… CONTINUE READING

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