DNA methylation in haematological malignancies: the role of decitabine.

Abstract

Normal cell development and function is dependent upon controlled gene expression. DNA methylation is an epigenetic modification that can play an important role in the control of gene expression. DNA methylation at cytosine residues in gene promoter CpG sequences is known to inhibit gene transcription. Inappropriate inhibition of the transcription of tumour… (More)

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@article{Hennessy2003DNAMI, title={DNA methylation in haematological malignancies: the role of decitabine.}, author={Bryan T. J. Hennessy and Guillermo Garc{\'i}a-Manero and Hagop M. Kantarjian and Francis Joseph Giles}, journal={Expert opinion on investigational drugs}, year={2003}, volume={12 12}, pages={1985-93} }