DNA methylation in esophageal diseases including cancer: special reference to hMLH1 gene promoter status.

@article{Vasavi2006DNAMI,
  title={DNA methylation in esophageal diseases including cancer: special reference to hMLH1 gene promoter status.},
  author={Mohan Vasavi and Shivani Ponnala and Kusumanjali Gujjari and Prabhakar Boddu and Ravi Shankar Bharatula and Rupender Prasad and Yog Raj Ahuja and Qurratulain Hasan},
  journal={Tumori},
  year={2006},
  volume={92 2},
  pages={
          155-62
        }
}
AIMS AND BACKGROUND Chronic inflammation leading to malignancy in the esophagus may be due to errors in mismatch repair (MMR) genes such as hMLH1. Promoter hypermethylation has been suggested as the main cause of hMLH1 silencing. In this study we assessed hMLH1 promoter hypermethylation in a range of esophageal diseases. Further, we evaluated the role of factors affecting the methylation cycle: (1) methylenetetrahydrofolate reductase (MTHFR) C677T mutation and (2) serum homocysteine levels… CONTINUE READING

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