DNA methylation in T cells from idiopathic lupus and drug-induced lupus patients.

@article{Zhou2008DNAMI,
  title={DNA methylation in T cells from idiopathic lupus and drug-induced lupus patients.},
  author={Ying Zhou and Qian-jin Lu},
  journal={Autoimmunity reviews},
  year={2008},
  volume={7 5},
  pages={
          376-83
        }
}
Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by the production of autoantibodies and the damage of multiple organs. T lymphocytes play an important role in the autoimmune responses. Epigenetic factors have significant effects on T-cell functions by modulating its DNA methylation pattern. Gene-specific DNA hypomethylation happens in T cells in patients with active lupus. 5-azacytidine (5-azaC), and other demethylating agents like procainamide and hydralazine… CONTINUE READING
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