DNA methylation impairs TLR9 induced Foxp3 expression by attenuating IRF-7 binding activity in fulminant type 1 diabetes.

@article{Wang2013DNAMI,
  title={DNA methylation impairs TLR9 induced Foxp3 expression by attenuating IRF-7 binding activity in fulminant type 1 diabetes.},
  author={Zhen Wang and Ying Zheng and Can Hou and Lin Yang and Xia Li and Jian Lin and Gan Huang and Qian-jin Lu and Congyi Wang and Zhiguang Zhou},
  journal={Journal of autoimmunity},
  year={2013},
  volume={41},
  pages={50-9}
}
Fulminant type 1 diabetes (FT1D) is an extremely aggressive disease characterized by the abrupt onset of insulin-deficient hyperglycemia. However, the precise mechanisms underlying disease etiology almost remain unclear. As mice deficient in regulatory T cells (Tregs) are prone to the development of an FT1D-like phenotype, we thus investigated whether FT1D patients manifest Treg deficiency and explored the related mechanisms. We first noted a significant reduction for Foxp3 and CTLA4 expression… CONTINUE READING