DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia.

@article{Milani2010DNAMF,
  title={DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia.},
  author={Lili Milani and Anders Lundmark and Anna Kiialainen and Jessica Nordlund and Trond Flaegstad and Erik Forestier and Mats Heyman and Gudmundur K J{\'o}nmundsson and Jukka A Kanerva and Kjeld Schmiegelow and Stefan S{\"o}derh{\"a}ll and Mats G. Gustafsson and Gudmar L{\"o}nnerholm and Ann-Christine Syv{\"a}nen},
  journal={Blood},
  year={2010},
  volume={115 6},
  pages={1214-25}
}
Despite improvements in the prognosis of childhood acute lymphoblastic leukemia (ALL), subgroups of patients would benefit from alternative treatment approaches. Our aim was to identify genes with DNA methylation profiles that could identify such groups. We determined the methylation levels of 1320 CpG sites in regulatory regions of 416 genes in cells from 401 children diagnosed with ALL. Hierarchical clustering of 300 CpG sites distinguished between T-lineage ALL and B-cell precursor (BCP) ALL… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

ML Den Boer, M van Slegtenhorst, RX De Menezes
Lancet Oncol • 2009
View 8 Excerpts
Highly Influenced

Acute lymphoblastic leukemia.

Pediatric clinics of North America • 1997
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…