DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

@inproceedings{Turan2011DNAMD,
  title={DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?},
  author={Nahid Turan and Mohamed F. Ghalwash and Sunita Katari and Christos Coutifaris and Zoran Obradovic and Carmen Sapienza},
  booktitle={BMC Medical Genomics},
  year={2011}
}
Infant birth weight is a complex quantitative trait associated with both neonatal and long-term health outcomes. Numerous studies have been published in which candidate genes (IGF1, IGF2, IGF2R, IGF binding proteins, PHLDA2 and PLAGL1) have been associated with birth weight, but these studies are difficult to reproduce in man and large cohort studies are needed due to the large inter individual variance in transcription levels. Also, very little of the trait variance is explained. We decided to… CONTINUE READING

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