DNA methylation differences associated with tumor tissues identified by genome scanning analysis.

@article{Liang1998DNAMD,
  title={DNA methylation differences associated with tumor tissues identified by genome scanning analysis.},
  author={Gangning Liang and Carol E Salem and Mimi C. Yu and Hung Nguyen and Felicidad A. Gonzales and T T Nguyen and Peter W. Nichols and Peter A. Jones},
  journal={Genomics},
  year={1998},
  volume={53 3},
  pages={260-8}
}
Most investigations on the role of DNA methylation in cancer have focused on epigenetic changes associated with known tumor suppressor genes. This may have led to an underestimation of the number of CpG islands altered by DNA methylation, since it is possible that a subset of unknown genes relevant to cancer development may preferentially be affected by epigenetic rather than genetic means and would not be identified as familial deletions, mutations, or loss of heterozygosity. We used a… CONTINUE READING
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