DNA methylation-dependent epigenetic regulation of dimethylarginine dimethylaminohydrolase 2 gene in trophoblast cell lineage.

@article{Tomikawa2006DNAME,
  title={DNA methylation-dependent epigenetic regulation of dimethylarginine dimethylaminohydrolase 2 gene in trophoblast cell lineage.},
  author={Junko Tomikawa and Kazumi Fukatsu and Satoshi Tanaka and Kunio Shiota},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 17},
  pages={
          12163-9
        }
}
Trophoblast cell lineage is established through the first cellular differentiation in mammalian embryogenesis, and its developmental potential is restricted to the extraembryonic tissues contributing solely to the placenta. Several lines of evidence suggest a relative lack of importance of DNA methylation in gene regulation in the extraembryonic tissues when compared with embryonic ones. Here we analyzed the dynamics of epigenetic status in the upstream region of mouse Ddah2 gene, which was… CONTINUE READING
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