DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma.

  title={DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma.},
  author={St{\'e}phanie Boireau and Michael Buchert and Michael S Samuel and Julie Pannequin and Joanne L Ryan and Armelle Choquet and H{\'e}liette Chapuis and Xavier R{\'e}billard and Christophe Avanc{\`e}s and Matthias Ernst and Dominique Joubert and Nicolas Mottet and Fr{\'e}d{\'e}ric Hollande},
  volume={28 2},
The expression pattern of tight junction (TJ) proteins is frequently disrupted in epithelial tumors. In particular, isoform- and organ-specific alterations of claudins have been detected in human cancers, highlighting them as interesting tools for the prognosis or treatment of various carcinomas. However, the molecular mechanisms responsible for these alterations are seldom identified. Here, we analyzed the expression and localization of claudins 1, 4, and 7 in human bladder carcinoma. Claudin… CONTINUE READING