DNA methylation changes in leukaemia.

  title={DNA methylation changes in leukaemia.},
  author={John R Melki and Susan J. Clark},
  journal={Seminars in cancer biology},
  volume={12 5},
Leukaemogenesis is a multi-step process whereby a clonal population arises that has undergone successive alterations to the genotype and the phenotype of the cells that make up the clone. Leukaemia has traditionally been viewed as a genetic disease, however epigenetic defects also play an important role. Expression of the DNA methyltransferase enzymes is elevated in leukaemia, and aberrant methylation is common with both a decrease in the total genomic 5-methylcytosine, and a concomitant… CONTINUE READING

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