DNA methylation changes in cells regrowing after fractioned ionizing radiation.

  title={DNA methylation changes in cells regrowing after fractioned ionizing radiation.},
  author={Christine Kuhmann and Dieter Weichenhan and Michael Rehli and Christoph Plass and Peter Schmezer and Odilia Popanda},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  volume={101 1},
BACKGROUND AND PURPOSE Repeated exposure to ionizing radiation (IR) can result in adaptive reactions. While DNA methylation changes in adaption to repeated stress exposure are established for a variety of drugs, their role in fractioned ionizing radiation is largely unknown. MATERIAL AND METHODS MCF7 breast cancer cells were treated 5 times a week with IR in fractions of 2 Gy, resulting in total doses of 10 and 20 Gy. Cells were harvested 48 and 72 h after the last irradiation, as well as… CONTINUE READING
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