DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors

@article{Laan2020DNAMC,
  title={DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors},
  author={Loora Laan and J. Klar and Maria Sobol and Jan Hoeber and M. Shahsavani and Malin Kele and Ambrin Fatima and M. Zakaria and G. Ann{\'e}ren and A. Falk and J. Schuster and N. Dahl},
  journal={Clinical Epigenetics},
  year={2020},
  volume={12}
}
  • Loora Laan, J. Klar, +9 authors N. Dahl
  • Published 2020
  • Biology, Medicine
  • Clinical Epigenetics
  • BackgroundDown syndrome (DS) is characterized by neurodevelopmental abnormalities caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down syndrome brain specimens has shown global epigenetic and transcriptional changes but their interplay during early neurogenesis remains largely unknown. We differentiated induced pluripotent stem cells (iPSCs) established from two DS patients with complete T21 and matched euploid donors into two distinct neural stages corresponding… CONTINUE READING
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    References

    SHOWING 1-10 OF 73 REFERENCES
    Identification of a DNA methylation signature in blood cells from persons with Down Syndrome
    • 69
    • PDF
    Global DNA Hypermethylation in Down Syndrome Placenta
    • 73
    • PDF
    Epigenetic dysregulation in the developing Down syndrome cortex
    • 40
    Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.
    • 30
    • Highly Influential
    • PDF
    Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in down syndrome
    • 74
    • PDF
    Altered DNA Methylation in Leukocytes with Trisomy 21
    • 90
    • PDF
    Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models
    • 45
    • Highly Influential
    • PDF