DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation.

@article{Santangelo2002DNAMC,
  title={DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation.},
  author={Samantha Santangelo and David J Cousins and Nicole E E Winkelmann and Dontcho Z. Staynov},
  journal={Journal of immunology},
  year={2002},
  volume={169 4},
  pages={1893-903}
}
The differentiation of naive CD4(+) T lymphocytes into Th1 and Th2 lineages generates either cellular or humoral immune responses. Th2 cells express the cytokines IL-4, -5, and -13, which are implicated in asthma and atopy. Much has been published about the regulation of murine Th2 cytokine expression, but studies in human primary T cells are less common. We have developed a method for differentiating human CD45RA(+) (naive) T cells into Th1 and Th2 populations that display distinct cytokine… CONTINUE READING
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