DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease.

@article{Ozaki2017DNAMC,
  title={DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease.},
  author={Yuki Ozaki and Yuta Yoshino and Kiyohiro Yamazaki and Tomoko Sao and Yoko Mori and Shinichiro Ochi and Taku Yoshida and Takaaki Mori and Jun-Ichi Iga and Shu-Ichi Ueno},
  journal={Journal of psychiatric research},
  year={2017},
  volume={92},
  pages={
          74-80
        }
}
OBJECTIVES Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. We previously reported that TREM2 mRNA is highly expressed in leukocytes of AD patients compared to those in healthy controls. However, the mechanism of TREM2 expression change is still not known. In this study, we examined the involvement of the DNA methylation status of TREM2 in its high gene… CONTINUE READING
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Citations

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SHOWING 1-10 OF 10 CITATIONS

TREM1 mRNA Expression in Leukocytes and Cognitive Function in Japanese Patients with Alzheimer's Disease.

  • Journal of Alzheimer's disease : JAD
  • 2018
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CITES METHODS, RESULTS & BACKGROUND
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DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function

  • International journal of molecular sciences
  • 2018
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TREM2 in Neurodegenerative Diseases

  • Molecular Neurodegeneration
  • 2017
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