DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding.

Abstract

The origin of aberrant DNA methylation in cancer remains largely unknown. In the present study, we elucidated the DNA methylome in primary acute promyelocytic leukemia (APL) and the role of promyelocytic leukemia-retinoic acid receptor α (PML-RARα) in establishing these patterns. Cells from APL patients showed increased genome-wide DNA methylation with… (More)
DOI: 10.1182/blood-2012-08-448860

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@article{Schoofs2013DNAMC, title={DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding.}, author={Till Schoofs and Christian Rohde and Katja Hebestreit and Hans-Ulrich Klein and Stefanie Goellner and Isabell Schulze and Mads Lerdrup and Nikolaj Dietrich and Shuchi Agrawal-Singh and Anika Witten and Monika Stoll and Eva Lengfelder and Wolf-Karsten Hofmann and Peter Schlenke and Thomas B{\"u}chner and Klaus Hansen and Wolfgang E. Berdel and Frank Rosenbauer and Martin Dugas and Carsten M{\"u}ller-Tidow}, journal={Blood}, year={2013}, volume={121 1}, pages={178-87} }