DNA methylation biomarkers of cancer: moving toward clinical application.

@article{Levenson2004DNAMB,
  title={DNA methylation biomarkers of cancer: moving toward clinical application.},
  author={Victor V. Levenson},
  journal={Pharmacogenomics},
  year={2004},
  volume={5 6},
  pages={
          699-707
        }
}
While different markers for cancer diagnosis have been known for at least a decade, the systematic search for biomarkers emerged only several years ago. In this article, I will concentrate on DNA methylation as a dynamic and robust platform for the development of cancer-specific biomarkers. Simultaneous analysis of a growing number of independent methylation events can create increasingly more precise and individualized diagnostics. The differential detection of methylated and unmethylated DNA… CONTINUE READING