Sensitive, specific blood-based tests are difficult to develop unless steps are taken to maximize performance characteristics at every stage of marker discovery and development. We describe a sieving strategy for identifying high-performing marker assays that detect colorectal cancer (CRC)-specific methylated DNA in plasma.
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Plum A Hildmann T Rujan T Eckhardt F Liebenberg V et al. Comparative DNA methylation analysis in normal Lewin J, tumour tissues, in cancer cell lines using differential methylation hybridisation. Int J Biochem Cell Biol 2007, 39