DNA methylation as a therapeutic target in cancer.

  title={DNA methylation as a therapeutic target in cancer.},
  author={Jean-Pierre Issa},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 6},
  • Jean-Pierre Issa
  • Published 2007 in
    Clinical cancer research : an official journal of…
Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on DNA methylation changes in cancer described global loss of methylation, which has been suggested to drive tumorigenesis through activation of oncogenic proteins or induction of chromosomal instability. In this context, reducing DNA methylation was viewed as a tumor-promoting event rather than a promising cancer therapy. The idea of inhibiting DNA methylation therapeutically emerged from subsequent studies… CONTINUE READING
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