DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

@inproceedings{Tobi2018DNAMA,
  title={DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood},
  author={Elmar W. Tobi and Roderick C. Slieker and Ren{\'e} Luijk and Koen Dekkers and Aryeh D Stein and Kate M Xu and Pieternella E Slagboom and Erik W van Zwet and L H Lumey and Bastiaan T Heijmans},
  booktitle={Science Advances},
  year={2018}
}
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide… CONTINUE READING
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Developmental Tuning of Epigenetic Clock

  • Front. Genet.
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 73 REFERENCES

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES).

  • International journal of epidemiology
  • 2015
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cohort profile: the Dutch Hunger Winter families study.

  • International journal of epidemiology
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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