DNA methylation and the functional organization of the nuclear compartment.

@article{Espada2010DNAMA,
  title={DNA methylation and the functional organization of the nuclear compartment.},
  author={Jes{\'u}s Espada and Manel Esteller},
  journal={Seminars in cell & developmental biology},
  year={2010},
  volume={21 2},
  pages={238-46}
}
Symmetrical methylation of cytosine residues at CpG dinucleotides of the DNA molecule is a central epigenetic and heritable hallmark of the genome. This epigenetic modification of DNA is directly associated with a closed molecular conformation of the chromatin fibre which is, in turn, intrinsically linked to an inactive transcriptional status. Thus, DNA methylation is a major determinant of the functional outcome of the nucleus. Equally important, DNA methylation is also involved in the large… CONTINUE READING