DNA methylation and structural and functional bimodality of vertebrate promoters.

@article{Elango2008DNAMA,
  title={DNA methylation and structural and functional bimodality of vertebrate promoters.},
  author={Navin Elango and Soojin V. Yi},
  journal={Molecular biology and evolution},
  year={2008},
  volume={25 8},
  pages={
          1602-8
        }
}
  • N. Elango, S. Yi
  • Published 1 August 2008
  • Biology
  • Molecular biology and evolution
Human promoters divide into 2 classes, the low CpG (LCG) and the high CpG (HCG), based on their CpG dinucleotide content. The LCG class of promoters is hypermethylated and is associated with tissue-specific genes, whereas the HCG class is hypomethylated and associated with broadly expressed genes. By analyzing several chordate genomes separated for hundreds of millions of years, here we show that the divide between low CpG and high CpG promoters is conserved in several distantly related… 
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