DNA methylation and not allelic variation regulates STAT6 expression in human T cells

@article{Kim2009DNAMA,
  title={DNA methylation and not allelic variation regulates STAT6 expression in human T cells},
  author={Eu-gene Kim and H Y Shin and Chang Geun Lee and Hye-Young Park and Yoon-Keun Kim and H R Park and Sang-Heon Cho and K -T. Min and Mi-La Cho and Sung-Hwan Park and Chang-woo Lee},
  journal={Clinical and Experimental Medicine},
  year={2009},
  volume={10},
  pages={143-152}
}
STAT6 transcription factor, which has been implicated in commitment to Th2, is known to be activated by IL-4 and IL-13. Accordingly, STAT6 is primarily responsible for the transcriptional effects of IL-4 and IL-13. STAT6-deficient mice are known to have defective IL-4-mediated functions, such as B cell proliferation, Th2 cell development and IgE secretion; therefore, they primarily contain the Th1 phenotype. However, the mechanism responsible for regulation of STAT6 expression transcriptionally… CONTINUE READING