DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype.

@article{Zhao2014DNAMA,
  title={DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype.},
  author={Ming Zhao and Siyang Liu and Shuangyan Luo and Honglong Wu and Meini Tang and Wenjing Cheng and Qing Zhang and Peng Fei Zhang and Xinhai Yu and Yudong Xia and Na Yi and Fei Gao and Li Wang and Susan Yung and Tak Mao Chan and Amr H. Sawalha and Bruce C. Richardson and M Eric Gershwin and Ning Li and Qian-jin Lu},
  journal={Journal of autoimmunity},
  year={2014},
  volume={54},
  pages={127-36}
}
Systemic lupus erythematosus (SLE) is an autoimmune disease well known for its clinical heterogeneity, and its etiology secondary to a cross-talk involving genetic predisposition and environmental stimuli. Although genome-wide analysis has contributed greatly to our understanding of the genetic basis of SLE, there is increasing evidence for a role of epigenetics. Indeed, recent data have demonstrated that in patients with SLE, there are striking alterations of DNA methylation, histone… CONTINUE READING