DNA methylation and hepatocarcinogenesis in rats fed a choline-devoid diet.

@article{Locker1986DNAMA,
  title={DNA methylation and hepatocarcinogenesis in rats fed a choline-devoid diet.},
  author={J. Locker and T. Reddy and B. Lombardi},
  journal={Carcinogenesis},
  year={1986},
  volume={7 8},
  pages={
          1309-12
        }
}
Groups of male Fischer-344 rats were fed either a choline-supplemented or a choline-devoid (CD) diet, for up to 14 months. In rats fed the CD diet, hepatic lesions developed and progressed through two distinct stages, the first characterized by severe steatosis and an increase in cell turnover and the second by gradual clearance of the deposited fat, fibrosis and parenchymal nodularity. Large hepatocellular carcinomas were found in rats killed at 14 months. DNA was purified from the livers of… Expand
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