DNA methylation and gene function.


In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. However, there is now reason to believe, from recent studies, that DNA methylation is a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.

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@article{Razin1980DNAMA, title={DNA methylation and gene function.}, author={Aharon Razin and Arthur D. Riggs}, journal={Science}, year={1980}, volume={210 4470}, pages={604-10} }