DNA methylation and gene activity.

@article{Cedar1988DNAMA,
  title={DNA methylation and gene activity.},
  author={Howard Cedar},
  journal={Cell},
  year={1988},
  volume={53 1},
  pages={3-4}
}
The above experiments support a relatively simple model to explain the role of DNA methylation in vivo. Most tissue-specific genes are methylated. The methyl groups may generate a local chromatin configuration that renders the genes inaccessible, and thus transcriptionally inactive. This would provide a general mechanism for transcriptional repression which may operate independent of the requirement for interactions between cis-acting regulatory elements and tissue-specific factors. In contrast… CONTINUE READING

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