DNA methylation and chromatin structure: the puzzling CpG islands.

@article{Caiafa2005DNAMA,
  title={DNA methylation and chromatin structure: the puzzling CpG islands.},
  author={Paola Caiafa and Michele Zampieri},
  journal={Journal of cellular biochemistry},
  year={2005},
  volume={94 2},
  pages={257-65}
}
DNA methylation is the epigenetic modification, which introduces 5mC as fifth base onto DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non-random fashion in genomic DNA so that methylation pattern is characterized by the presence of methylated cytosines on the bulk of DNA while the unmethylated ones are mainly located within particular regions termed CpG islands. These regions represent about 1% of genomic DNA and are generally found in the promoter… CONTINUE READING

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