DNA methylation analysis triggered by bulge specific immuno-recognition.

Abstract

We report the sequence-selective discrimination of the cytosine methylation status in DNA with anti methylcytosine antibody for the first time. This was realized by employing an affinity measurement involving the target methylcytosine in a bulge region and anti methylcytosine antibody, following hybridization with a bulge-inducing DNA to ensure that only… (More)
DOI: 10.1021/ac301702y

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