DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.

@article{dhePaganon2011DNAMT,
  title={DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.},
  author={Sirano dhe-Paganon and Farisa Syeda and Lawrence S. Park},
  journal={International journal of biochemistry and molecular biology},
  year={2011},
  volume={2 1},
  pages={58-66}
}
DNA methylation serves as the principal form of post-replicative epigenetic modification. It is intricately involved in gene regulation and silencing in eukaryotic cells, making significant contributions to cell phenotype. Much of it is mitotically inherited; some is passed on from one filial generation to the next. Establishment and maintenance of DNA methylation patterns in mammals is governed by three catalytically active DNA methyltransferases - DNMT3a, DNMT3b and DNMT1. While the first two… CONTINUE READING
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