DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

@article{Debenham1982DNAmediatedTO,
  title={DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.},
  author={Paul Debenham and Norbert Kartner and Louis Siminovitch and John R. Riordan and Victor Ling},
  journal={Molecular and cellular biology},
  year={1982},
  volume={2 8},
  pages={881-9}
}
Colchicine-resistant Chinese hamster ovary (CHO) cell mutants whose resistance results from reduced drug permeability have been isolated previously in our laboratories. This reduced permeability affects a wide range of unrelated drugs, resulting in the mutants displaying a multiple drug resistance phenotype. A 170,000-dalton cell surface glycoprotein (P-glycoprotein) was identified, and its expression appears to correlate with the degree of resistance. In this study we were able to confer the… CONTINUE READING

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