DNA-mediated anisotropic mechanical reinforcement of a virus.

@article{Carrasco2006DNAmediatedAM,
  title={DNA-mediated anisotropic mechanical reinforcement of a virus.},
  author={Carolina Avila Carrasco and Aura Carreira and Iwan A T Schaap and P. A. Serena and Julio G{\'o}mez-Herrero and Mauricio G Mateu and Pedro J de Pablo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 37},
  pages={13706-11}
}
In this work, we provide evidence of a mechanism to reinforce the strength of an icosahedral virus by using its genomic DNA as a structural element. The mechanical properties of individual empty capsids and DNA-containing virions of the minute virus of mice are investigated by using atomic force microscopy. The stiffness of the empty capsid is found to be isotropic. Remarkably, the presence of the DNA inside the virion leads to an anisotropic reinforcement of the virus stiffness by… CONTINUE READING

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