DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis.

@article{Kerem1989DNAMH,
  title={DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis.},
  author={B S Kerem and Julie A. Buchanan and Peter Durie and M L Corey and Henry Levison and Johanna M Rommens and Manuel Buchwald and L C Tsui},
  journal={American journal of human genetics},
  year={1989},
  volume={44 6},
  pages={827-34}
}
Patients with cystic fibrosis (CF) generally suffer from chronic obstructive lung disease, pancreatic insufficiency (PI), and a number of other exocrine malfunctions. Approximately 15% of CF patients are, however, pancreatic sufficient. To investigate whether the two clinical subgroups, PI and pancreatic sufficiency (PS), are caused by different CF mutant alleles, we have performed linkage disequilibrium and haplotype association analysis with three DNA markers that are tightly linked to the CF… CONTINUE READING

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