DNA ligase IV as a new molecular target for temozolomide.

Abstract

Temozolomide (TMZ) is a methylating agent used in chemotherapy against glioblastoma. This work was designed to clarify details in repair pathways acting to remove DNA double-strand breaks (DSBs) induced by TMZ. Cultured mouse embryonic fibroblasts were used which were deficient in DSB repair genes such as homologous recombination repair-related genes X-ray… (More)
DOI: 10.1016/j.bbrc.2009.07.045

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