DNA lesion complexity and induction of apoptosis by ionizing radiation.

@article{Radford2002DNALC,
  title={DNA lesion complexity and induction of apoptosis by ionizing radiation.},
  author={Ian R Radford},
  journal={International journal of radiation biology},
  year={2002},
  volume={78 6},
  pages={457-66}
}
  • Ian R Radford
  • Published 2002 in International journal of radiation biology
PURPOSE To determine whether murine lymphoid cell lines can discriminate between high- and low-LET (linear energy transfer) radiation-induced DNA lesions. MATERIALS AND METHODS Sensitivity to killing by DNA-incorporated 3H and 125I decays, accumulated during storage in the gas phase of a liquid nitrogen tank, was determined by clonogenic survival assay. RESULTS Induction of a lethal event in the STRij-4-2.2, WEHI-22.1, and L5178Y-R cell lines required approximately 30 times more 3H than… CONTINUE READING

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