DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues.

@article{Dusre1990DNAIC,
  title={DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues.},
  author={L Dusre and Sankaran Rajagopalan and H M Eliot and Joseph M. Covey and Birandra Kumar Sinha},
  journal={Cancer research},
  year={1990},
  volume={50 3},
  pages={648-52}
}
A subline of the human breast tumor cell line (MCF-7), selected for resistance to Adriamycin and having the multidrug resistance phenotype, also developed significant cross-resistance to mitomycin C and its two analogues, BMY 25282 and BMY 25067. Because mitomycin C and the analogues contain both quinone and aziridine moieties, the mechanism of tumor cell kill is thought to involve alkylation and cross-linking of DNA molecules, hence they are not expected to show cross-resistance to cells… CONTINUE READING

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References

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Showing 1-10 of 34 references

Resistance to alkylating agents: basic studies and therapeutic implications

  • E. Frei, Ill, +5 authors P. Grnereux
  • Mechanism of Drug Resistance in Neoplastic Cells,
  • 1988
1 Excerpt

Mitomycin C resistant LI210 cells: association with pleotropic drug resistance

  • R. T. Dorr, J. D. Liddle, J. M. Trent, W. S. Dalton
  • Biochem. Pharmacol.,
  • 1987
1 Excerpt

Circumvention of deficient activation in mitomycin C-resistant human colonie carcinoma cells by mitomycin C analog BMY 25282

  • S. Chakrabarty, Dañéis, Y.J.. Long, V B.H..Willson.J.K., G Brattain.M.
  • Cancer Res.
  • 1986
1 Excerpt

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